Rate of descent (as in vertical speed), can't really be a target, but more a reference as in, there are safe/comfortable limits.
I've never flown big airplanes, but I imagine it's similar to the small stuff. You have decent airspeed targets, and then adjust for the winds. For example: A descent that starts at FL330, could very well have extreme head/tailwinds to deal with.
An FMS will take care of all the adjustments.. or a crew can just try to keep the altitude/distance ratio near 3:1 (3,000 feet for every 10 miles out)..
**this is just an educated guess**
Edit: Ooops.. forgot the original question

But I'd imagine it's similar.. i.e.. target airspeeds and adjustments for winds.