I think that most people with any interest in aviation have wondered at some time whether they could land an airliner if the crew were incapacitated. While most of my real-life experience is on light aircraft I think I could make a pretty good go of it - with some expert assistance on the ground. It might not be pretty to watch but they would stand more chance with me than a complete beginner with no knowledge of flying. However big & complex the aircraft is the basic principles remain the same.
I suspect the same goes for anyone used to the MS sims. While I've always thought they concentrate too much on the panel & instruments in MSFS this might not be such a bad thing. At least you would have some idea of how it all works, more knowledge than me as I've never used the autopilot in FS.
I sat in the right-hand seat of a Boeing 707 flight simulator during a demonstration "flight" many years ago. It had the full six-axis motion system & was one of the first examples with a computerised display projected onto a curved mirror surrounding the outside of the cockpit, very similar to the ones used today by most airlines. It had been built for an airline & was actually used for training their pilots before being dismantled & shipped off to wherever the airline was based, China if I remember correctly. Very realistic & quite unlike anything I've seen on the PC. Maybe it's different with some of these simpits.
PS. This was at Rediffusion Flight Simulation (Redifon) at Crawley near Gatwick Airport. Redifon was one of the pioneers of modern flight simulation & my brother was Shipping Manager with the company for many years. They had open days every year where employees & their friends & families could see & experience the latest developments. About the same time as my 707 "flight" they were also experimenting with ideas for the leisure market & the "Back to the Future" ride at Universal Studios in Orlando was one of their first contracts. This works on exactly the same principle as their flight simulators & is still one of the best rides I've ever been on.