http://en.wikipedia.org/wiki/F-15#Satellite_killer
Satellite killer
From January 1984 to September 1986, an F-15A was used as a launch platform for five ASM-135 ASAT missiles. The F-15A went into a supersonic climb and released the ASAT missile at an altitude of 11.6 km (38,000 ft). The F-15A computer was updated to control the zoom-climb and missile release. The third test flight involved a retired communications satellite in a 555 km orbit, which was successfully destroyed by sheer kinetic energy. The pilot, USAF Major Wilbert D. "Doug" Pearson, became the first pilot ever to destroy an orbiting satellite.
The ASAT missile was designed to be a standoff anti-satellite weapon, with the F-15A acting as a first stage.