Closed... and confirmed mouseproof.

Both rigs have big fans in front and back. I don't have the duct and fan in place on the side of the newer case (doggone Zalman "doughnut" is too big), but I never have temp issues, because the 120mm rear fan is right there to carry that heat away from the CPU cooler.
As long as the fans/filters are kept clean and the case is not up against something where airflow in and out is restricted, I find the "flow" method rather than the "radiant" method works just fine.
Food for thought: aircraft engines are not just cowled to reduce drag- they are designed to maximize air flow over the cylinders and sometimes the oil pan. And that's not just for ground ops- even in flight, the air flow can and should be improved. The same physics apply to the guts of your computer.