To shut down or not to shut down that is the ?

[Politically Incorrect]

I have tried FSAuto Start and like it, seems to help some.
But I wondered if using the Ctrl/Alt/Delete method of shuting down applications and processes which ones are ok to kill??
Or it might be easier knowing which ones are important to leave on
Reason I would like to know is I have other games that I like to use that FSAS won't work with, I also use End-it-all but if there is a list of app's and processes that need to stay running it would be greatly appreciated!
Thanks!!

[Iroquois]

Anything with your name next to it except explorer.exe is ok to shut down. I usually close everything in the task bar but I keep my firewall and antivirus on. You can turn these off if your not connected to the internet. Do not shut down SYSTEM and LOCAL SERVICE applications as these will destabalize the OS.