nhancer woes

My trouble is Nvidia video cards and I believe nhancer is the solution. I have nhancer installed but it may not be working. Suggestions appreciated.
Computer: Vista64, Gigabyte UD5 MB, with i7 920 @ 4GHz, 6BG DDR3 1600 ram, 7200rmp 500GB hd, 30" monitor @ 2560x1600 res.
I've been able to get good results with an ATI4850 card, but I prefer using my more powerful Nvidia 8800GTX.
* After uninstalling ATI card and installing Nvidia drivers and 8800GTX, I installed nhancer 2.4.2. Since Microsoft Net Framework 2.0 wouldn't install on my 64 bit system I instead installed Net Framework 3.5.
With the MS Flight Simulator X profile highlighted I made all of NickN's suggested changes, but the computer ran very jerky with artifacts and sometimes very low frame rates. Obviously I didn't do something right. I tried turning antistropic filtering on and off but saw no results in MSFS X.
Questions:
Do I need to shut down MSFS X and restart it every time I make a change in nhancer?
Does nhancer work immediately or do I have to rebook my computer?
What activates changes in nhancer so that MSFS X is affected by these changes?
Is Vista64 supported by nhancer? The help page for nhancer doesn't list Vista as a supported operating system, but that support page may be in need of update (it talks about this "new" concept called SLI).
thx!
Computer: Vista64, Gigabyte UD5 MB, with i7 920 @ 4GHz, 6BG DDR3 1600 ram, 7200rmp 500GB hd, 30" monitor @ 2560x1600 res.
I've been able to get good results with an ATI4850 card, but I prefer using my more powerful Nvidia 8800GTX.
* After uninstalling ATI card and installing Nvidia drivers and 8800GTX, I installed nhancer 2.4.2. Since Microsoft Net Framework 2.0 wouldn't install on my 64 bit system I instead installed Net Framework 3.5.
With the MS Flight Simulator X profile highlighted I made all of NickN's suggested changes, but the computer ran very jerky with artifacts and sometimes very low frame rates. Obviously I didn't do something right. I tried turning antistropic filtering on and off but saw no results in MSFS X.
Questions:
Do I need to shut down MSFS X and restart it every time I make a change in nhancer?
Does nhancer work immediately or do I have to rebook my computer?
What activates changes in nhancer so that MSFS X is affected by these changes?
Is Vista64 supported by nhancer? The help page for nhancer doesn't list Vista as a supported operating system, but that support page may be in need of update (it talks about this "new" concept called SLI).
thx!