Well, it obviously works differently with different games, different drivers etc.
But with the Geforce control panel, you can set it up differently for each game, and save the set-up. I use Vertical sync ON with some games like CFS3, OFF with others - same with anti-aliasing and anisotropic filtering.
I'd be interested to know what other settings from the Geforce control panel that you have ON or OFF with CFS3.