Assassin's Creed Brotherhood, which is held in Rome, Italy, features a Colosseum, aged for it's time line!
One is the 1503 Colosseum, lived out by Ezio Auditore Da Firenze, the protagonist
The other is the modern day one, in 2010 (release year of AC Brotherhood), which is visited by Desmond Miles, the guy whose memories of Ezio are lived out through the DNA
Roma, 1503, Under the Papal Army of Pope Alexander VI (Rodrigo Borgia)
Rome, 2010 (Modern Day Sequence)