Well, to add my two cents, and to highlight what I think Brett is getting at...
...I belive such a platform would cost far too much to be viable. The beauty of the VC-25 is that it is furbished mainly for its role of carrying the president. With some satellite communications. The airframe is relatively cheap.
The beauty of the E-4B, is that it has a dedicated purpose of being the doomsday airplane. Radiation filters, hi-band satellite antenna etc. There is a relatively high need for multiple aircraft too.
ONE A380 costs around 317 MILLION USD. An A380 without a comms suite, and other military requirements.
One E-4B costs about 200 million.
One VC-25 costs 325 million.
Priced when?
Without comms suite and other military requirements, a VC-25 is a standard green 747-200. E-4B ditto. B747-200 is not for sale now, it is out of production. A green B747-800 is about US$ 250 millions or so. Fitting it out extra with comms suite would cost a lot on top of that.
Buying two A380s and refurbishing them as a cross between the VC-25 and the E-4B would be too expensive.
US AF is asking for 3 planes, to be delivered in 2017, 2019 and 2021. And they are considering A380 as option.
If they use this only to replace VC-25, they are spending huge sums to replace two VC-25 747-s with 3 A380-s that are VC-25 plus a lot of unused space, and they still have to be trailed by the then very old E-4B-s. If they equipped that excess space of those three A380-s with the E-4B functionality, they could ground most of the 4 E-4B-s and achieve savings thereby.