Throttle question for Twin Pilots

I have 2 Saitek throttle quadrants side by side.
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There's no really "acceptable differences" written on paper that I know of (and if there is, it is expected it should change between a plane and another). If an engine begins straying too much from the expected parameters, it simply means it needs to overhauled, but unless you use some complex payware with very complex damage modules that work per engine, I don't think you need to worry about this.
Limitations of the system.
the levers might be in-line at 21", but not 25" of manifold-pressure
In every twin I've flown, the throttles or power levers have not been perfectlly lined up while the engines are at the same power setting.