Never use airbrakes when you have more than 15 flaps in. In RL, it is basically forbidden to use full deployment of them while you're in the air, they would probably get sheared off if you were going to fast-but in FS, we don't have the luxury of the "flight detent" setting, so you should only deploy the speedbrakes for very short periods of time, and never when you have A/T (autothrottle engaged), because it'll just throttle up and cancel out any speed reduction.
In short-don't leave them deployed for too long. They "spoil" lift. Ya know, that great thing that makes the airplane fly. Only for short periods of time while in flight.

EDIT: Oops. Just read that he was refering to fighter jets, I always automatically think commercial.

Someone else would be much better qualified to explain fighter ops than me, but everything I wrote still applies to the big(ger) jets.