nHancer Combined 4xS WAY OFF
Nick, I hope you're reading this now
Flight Simulator and other chat
https://forums.simviation.com/phpBB3/
https://forums.simviation.com/phpBB3/viewtopic.php?f=21&t=64003
.Check your running resolution and make sure it matches your screen size.
Experiment with each resolution.
.Just do it in windowed mode.

I guess it could be a combination of the card age, drivers and Vista
but as I said.. I have never seen this issue before. If you happen to come aross something that makes a change please post it