MAJOR LAUNCH PROBLEM

HELP PLEASE !!
I've never had this one before!
Running XP and launching fs9, I now consistently get this message:
"Your computer has run out of memory.Flight Simulator will now exit.You may not have enough free space on your hard drive.Run Disk Cleanup to free up space, and then try running Flight Simulator again."
Can somebody please help?
I've never had this one before!
Running XP and launching fs9, I now consistently get this message:
"Your computer has run out of memory.Flight Simulator will now exit.You may not have enough free space on your hard drive.Run Disk Cleanup to free up space, and then try running Flight Simulator again."
- There is plenty of space on my HD
I've done all the cleanup and defrags anyway
I havn't added any new hardwear, softwear or outrageously large file
In fact I have changed nothing!
I have tried re-installing, AND EVEN installing on another drive without it making any difference; after launching a couple of times I get the same error message again.
Can somebody please help?