Midnight, I'm refering to cruise in a large plane. In cruise flight, GS is the most important because ETA IS the most important to airline pilots.
Of COURSE KIAS is important in low speed situations. However. at cruise, the FMC will give you the wind. Jet pilots do not look to their IAS for the winds-they do keep a very, very close eye on GS.
I have more than 10 hours of RL xcountry time in a 172, so you're preaching to the choir here-although I must say in RL we don't really look the the KIAS for the wind speed either, but we could I suppose

(we're more concerned with wind direction when in cruise, we get the speed from FSS and at the airport we have ASOS, AWOS and ATIS to give us the speed, no need to figure it out based on KIAS v. GS)
Now why would some flights going to Europe be faster and doesn't use much fuel as the returning flights to the USA?
That's because the jetstream flows from the west to the east!
Now you're
really preaching to the choir-I could tell you the general winds aloft situations of every region of the US

(600+ hrs logged commops in FS, and believe me I pay attention to winds in the flightplanning) GS is STILL more important in these situations, KIAS is too unreliable at that altitude-GS gives it to you straight. For example-
Flight plans will have the speeds from checkpoint-to-checkpoint in GS, not KIAS. So if you want to get a rough estimate as to your timing, all you need to do is compare your current GS with that of which you planned your ETA with. If, at 475 kts GS it was going to take me 16 minutes to get somehwere, and I'm doing 450 kts, I know I'm going to be a little late.