My personal opinion I have had great luck with Creative products but you must be certain to have the drivers updated just like you would a video card.
The only conflict I have had with Sound Blaster Audigy 2 ZS was when looking at the kneeboard and scrolling the lines would run together. This was solved by going to the Creative Website and updating the drivers.
I guess I never mentioned how much I hate CREATIVE products on this forum eh? Well, now you know why, with supporting evidence above
That evidence doesn't support nothing. The only thing it supports is the fact that the apparent problem has been narrowed down to a sound card/ video card conflict. It doesn't support that Creative products are crap.
Like Gixer states "wasn't methodical enough."
Most conflicts are a direct result of improper video driver removal, He has already stated that he was running Nvidia cards before the ATI, I bet that there is your conflict there are remnents of the Nvidia drivers still there due to improper use of the Driver Cleaner utility.
Follow what Gixer says about running it in Safe Mode, this will make all the differance.
After properly uninstalling the driver update with the new ones (remebering that just because it might be the newest released driver, doesn't mean it will be the best for your computer!!!) ex. I have a FX 5200 which runs worth crap with the newest driver available, but runs awesome with the 61.11.
So if the most recent driver doesn't show good results try a older one (making sure you correctly remove a driver before installing another!).
Then be certain to go and check for updated sound card drivers!!!!