Jordonj:
Mixture and prop settings can be tricky to get; but once you figure it out it's easy.
1) Mixture. To control mixture; the gauge you read is the EGT; or 'Exhaust Gas Temperature'. This will tell you if your engine is running too lean (EGT gets hotter) or too rich (EGT gets cooler). But for FS purposes; it's far easier to just listen for it. Bring the mixture back just a wee bit every thousand feet of climb; keeping the engine sound strong. If it drops off; adjust mixture until it sounds strong again. It's a lot faster than using the EGT; the gauge takes a few seconds to move.
Basically; use the ear for climbing; then once you're in cruise; use the EGT for fine-tuning.
2) Prop setting. Most of the planes in the game with an adjustable propeller use a constant-speed prop.
It works kinda like a gear shift - when you need power; such as during takeoff, climb and landing (basically doing anything interesting with the bird); keep it fully fine - i.e. fuly forward. Without going into technical detail; this gives the engine maximum grunt to pull the plane forward. Once you're in cruise; set the prop to what it says in the checklist. If the checklist doesn't have that info (it will); try to adjust the prop so the prop RPM needle is around the bottom end of the green arc.
This is general only - your best bet is to look up the appropriate numbers in the manual and use them.

Cheers!