My Rwy12 install works just fine. (and has done so for the past year-or-so). May I suggest lurking at the
Rwy12 Forum and registering for FREE if you choose.
I worked across drives using WIN3.0; WIN3.1 and WIN98. When WIN-ME came out I vowed never to work across drives again. IMO, it's more trouble than it's worth.
My FS9 was installed the day-it-came-out on a new WIN-XP machine using just the one drive: C:
P.S. I can still use all my installed Rwy12 Libraries with EZ-Scenery -- cool.