It seems that the glide ratio L/D of airliners has not changed since 1950-s or even 1930-s. The numbers are something like 16...18.
Gliders are said to have achieved glide ratio of over 60 already in 1970-s. The current record L/D of a whole, manned airframe is held by a powered plane named ETA, and is 72.
Global Flyer is said to enjoy a glide ratio of 37. It has long, narrow wings: wingspan about 35 m, wing area 40 square metres.
Global Flyer is constrained in design by the huge fuel load (10 tons MTOW, 1600 kg ZFW... very limited structural mass available, and needs to stay efficient over a wide range of weights). Also, as a jet it has relatively high Mach numbers and also is constrained by the time the solo pilot can fly without sleeping.
U-2 is said to have glide ratio of 28. And it has wingspan of something like 31 m, wing area of 95 square metres... 1950-s design (back at the time when the L/D of gliders was in 40-s or less, not past 60), a jet plane, flying at high subsonic Mach numbers... and achieved L/D that large.
What is the main technical issue preventing more extensive use of planes having L/D in the 20...25 range?