Access Denied

Does anyone know how to make Vista allow me to make changes to some different files?
For example:
When I try to update FEX, I get this error -

And when I try to edit a panel.cfg file in FSX, I get this error -

Any help would be greatly appreciated.
For example:
When I try to update FEX, I get this error -
And when I try to edit a panel.cfg file in FSX, I get this error -
Any help would be greatly appreciated.