It depends. Look at the how-to section of flightsim.com. Some people just hook the pots up to USB and some use gears, or pistons.
Unfortunately you can't hook pots DIRECTLY up to USB... you need an interface circuit in there. But hooking up to gameports is easier and that CAN take straight pots.
Usually the "deal" with using an old joystick is to use the joystick's existing usb interface and hook the pots up via a new mechanical linkage to a homebuilt throttle quadrant. Then you assign the functions in the joysticks section of the setup part of the sim.
However... if you are running multiple throttles... you have a little problem possibly sneaking in there. At any given physical setting of the two or more throttle levers... the resistance of the pots may not match exactly. That will translate to eneven thrust. So you'll have to individually "tune" the levers when you are slying.
Real controls for throttle quadrants have some "smarts" built in that make the individual throttles assume the same setting if thay are set within a certain range of each other. It kind of "averages" the 2, 3, or 4 resistance values being produced.
There is more info here on this kind of stuff too.
best,
....................john

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